Hazuki Kotani

Rapid enhancement of antibiotic resistance and divergent remodeling of gene expression in single cells of bacteria

This study shows that antibiotic resistance in E. coli emerges rapidly in single cells under chloramphenicol exposure through phenotypic heterogeneity and gene expression remodeling.

Closed-loop steering locates an evolutionary barrier to multidrug resistance in Escherichia coli

The paper uses a closed-loop system to steer Escherichia coli toward multidrug resistance and identifies an evolutionary barrier linked to mutations in the efflux pump gene.

Context-dependent activation and evolutionary buffering of a mating pheromone in fission yeast

The paper shows how mutations in a mating pheromone can change function based on environmental conditions and how compensatory mutations allow evolutionary adaptation.

High-Throughput Laboratory Evolution Of Escherichia coli Under Multiple Stress Environments

This study uses high-throughput lab evolution of E. coli under stress conditions to identify gene expression changes and mutations linked to stress resistance.