Widespread purine bias in bacterial genes driven by runaway transcription
K. Julia Dierksheide, James Taggart, Grace E. Johnson, Gene‐Wei Li
The paper shows that purine bias in bacterial genes prevents premature transcription termination by evading Rho-dependent termination, leading to biased codon usage in species with runaway transcription.
bioRxiv · Aug 25, 2025 · PreprintMicrobiology