James Taggart

Long-range mRNA folding shapes expression and sequence of bacterial genes

The paper shows that long-range mRNA folding affects ribosome binding site accessibility, leading to gene expression regulation and sequence evolution constraints.

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

The paper identifies a genetic variant that protects against clonal hematopoiesis by regulating RNA-binding protein MSI2 in hematopoietic stem cells.

Widespread purine bias in bacterial genes driven by runaway transcription

The paper shows that purine bias in bacterial genes prevents premature transcription termination by evading Rho-dependent termination, leading to biased codon usage in species with runaway transcription.

A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis

The paper identifies endonucleolytic cleavage sites in Bacillus subtilis using transcriptome-wide mapping and deep mutational scanning, revealing distinct sequence determinants for different endoribonucleases.