David Shorthouse

Positive selection and structural disruption of KCNA5 by mutation in colorectal cancer

The paper identifies KCNA5 mutations under positive selection in colorectal cancer and shows they disrupt channel structure and function, affecting tumor pathways.

Validating folding energy estimates as a method for variant interpretation

This study validates folding energy estimates for variant interpretation, showing that while correlation coefficients are low, the method can improve prediction accuracy by identifying and addressing outlier residues.

Identification of molecular pathways involved in the anti-liver cancer activity of madecassic acid

This study identifies molecular pathways of madecassic acid's anti-liver cancer activity using chemical proteomics and RNAseq, showing its interactions with proteins related to metabolism and nucleic acid processing.

A Toolbox for Discrete Modelling of Cell Signalling Dynamics

The paper introduces a library of discrete target functions for cell signalling models using BioModelAnalyzer, showing they can predict genetic perturbations with limited data.