Epigenetic modulators link mitochondrial redox homeostasis to cardiac function
Zaher Elbeck, Mohammad Bakhtiar Hossain, Humam Siga, Nikolay Oskolkov, Fredrik Karlsson, Julia Lindgren, Anna Walentinsson, Dominique Koppenhöfer, Rebecca E. Jarvis, Roland W. Bürli, Tanguy Jamier, Elske H. P. Franssen, Mike A. Firth, Andrea Degasperi, Claus Bendtsen, , Christer Betsholtz
The paper shows that IDH2, a mitochondrial enzyme, acts as a major antioxidant defense in cardiomyocytes, with its activity compensating for reduced expression in heart failure, and identifies an epigenetic mechanism linking oxidative stress to cardiac function.
Nature Communications · Mar 20, 2024Peer-reviewedMolecular Biology