Targeting IRE1alpha improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
Dan Wu, Venkateswararao Eeda, Zahra Maria, Komal Rawal, Audrey Wang, Oana Herlea‐Pana, Ram Babu Undi, Hui‐Ying Lim, Weidong Wang
This study shows that inhibiting IRE1 improves insulin sensitivity, thermogenesis, and reduces metabolically active adipose tissue macrophages in obese mice.
bioRxiv · Jul 17, 2024Cell Biology