Author

Alexander W. E. Franz

University of MissouriORCID 0000-0002-3243-8408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Genomics· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Yingjun CuiiD· 2 shared Adeline E. WilliamsiD· 1 shared Awadalkareem Adam· 1 shared Courtney B. WoolseyiD· 1 shared David G. Rehard· 1 shared Divya P. ShindeiD· 1 shared Hannah Lu· 1 shared Irma Sánchez-VargasiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

Yingjun CuiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

Awadalkareem Adam, Courtney B. Woolsey, Hannah Lu, Kenneth S. Plante, Shannon M. Wallace, Leslie Rodriguez, Divya P. Shinde, Yingjun Cui, Alexander W. E. Franz, Saravanan Thangamani, Jason E. Comer, Scott C. Weaver, Tian Wang

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

npj Vaccines · Dec 19, 2024Peer-reviewedMicrobiology

Performance of low-threshold, population replacement gene drives in cage populations of the yellow fever mosquito, Aedes aegypti

Zachary J. Speth, David G. Rehard, Patricia Norton, Alexander W. E. Franz

This study tests two CRISPR-Cas9 gene drives in Ae. aegypti cage populations, showing they increase in frequency and exhibit super-Mendelian inheritance.

bioRxiv · Aug 6, 2024 · PreprintGenetics

Assessing single-component gene drive systems in the mosquito Aedes aegypti via single generation crosses and modeling

William R Reid, Adeline E. Williams, Irma Sánchez-Vargas, Jingyi Lin, Rucsanda Juncu, Ken E. Olson, Alexander W. E. Franz

This study evaluates CRISPR/Cas9-based gene drive systems in Aedes aegypti by analyzing indel accrual, maternal effects, and fitness costs to model GD fixation rates.

bioRxiv · Dec 8, 2021 · PreprintSynthetic Biology

Heterogeneity of midgut cells and their differential responses to blood meal ingestion by the mosquito, Aedes aegypti

Yingjun Cui, Alexander W. E. Franz

This study uses snRNA-Seq to analyze midgut cell diversity in Aedes aegypti and shows how blood meal ingestion alters cell composition and gene expression.

Insect Biochemistry and Molecular Biology · Nov 11, 2020Peer-reviewedGenomics