Author

Davide Lecca

University of MilanORCID 0000-0002-3258-363XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Maria P. AbbracchioiD· 2 shared Andrea Domenico RiveraiD· 1 shared Arthur Morgan ButtiD· 1 shared Carola TorazzaiD· 1 shared Davide MarangoniD· 1 shared Elena Maria Chinosi· 1 shared Eva Kildall HejbøliD· 1 shared Francesca Carolina MannellaiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Maria P. AbbracchioORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyPharmacological ResearchPeer-reviewedSep 1, 2026

Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice

Stefano Raffaele, Tiziana Bonifacino, Francesca Carolina Mannella…·Marta Fumagalli

This study shows that targeting GPR17 in oligodendrocytes improves myelin and motor function in female ALS mice but not males.

DOI 10.1016/j.phrs.2026.108424

mousebulk RNA-seq

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NeuroscienceAging CellPeer-reviewedMar 5, 2021

Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain

Andrea Domenico Rivera, Francesca Pieropan, Irene Chacon De La Rocha…·Arthur Morgan Butt

The paper identifies GPR17 as a key regulator of OPC dysfunction in aging and identifies potential therapeutic agents to restore myelination.

61 citationstop 4%

mousebulk RNA-seq

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