Author

Irene Chacon De La Rocha

University of PortsmouthORCID 0000-0001-9017-9371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Andrea Domenico RiveraiD· 3 shared Arthur Morgan ButtiD· 3 shared Diego Gómez‐NicolaiD· 2 shared Gemma L. Fryatt· 2 shared Olivier RaineteauiD· 2 shared Alexei VerkhratskyiD· 1 shared Davide LeccaiD· 1 shared Francesca PieropaniD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Andrea Domenico RiveraORCID

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3 papers

Recent·Most cited

Functional genomic analyses highlights a shift in Gpr17-regulated cellular processes in oligodendrocyte progenitor cells (OPC) and underlying myelin dysregulation in the aged forebrain

Andrea Domenico Rivera, Francesca Pieropan, Irene Chacon De La Rocha, Davide Lecca, Maria P. Abbracchio, Kasum Azim, Arthur Morgan Butt

The paper identifies GPR17 as a key regulator of OPC dysfunction in aging and identifies potential therapeutic agents to restore myelination.

Aging Cell · Mar 5, 2021Peer-reviewedNeuroscience

Accelerated dystrophy and decay of oligodendrocyte precursor cells in the APP/PS1 model of Alzheimer's-like pathology

Irene Chacon De La Rocha, Gemma L. Fryatt, Andrea Domenico Rivera, Alexei Verkhratsky, Olivier Raineteau, Diego Gómez‐Nicola, Arthur Morgan Butt

The paper examines age-related changes in oligodendrocyte precursor cells (OPCs) in APP/PS1 mice, showing accelerated dystrophy and decay compared to non-transgenic controls.

Frontiers in Cellular Neuroscience · Dec 2, 2020Peer-reviewedNeuroscience

Synaptic silencing affects the density and complexity of oligodendrocyte precursor cells in the adult mouse hippocampus

Irene Chacon De La Rocha, Gemma L. Fryatt, Andrea Domenico Rivera, Laura Restani, Matteo Caleo, Olivier Raineteau, Diego Gómez‐Nicola, Arthur Morgan Butt

This study shows that synaptic silencing reduces oligodendrocyte precursor cell density and complexity in adult mouse hippocampus.

bioRxiv · Sep 23, 2020 · PreprintNeuroscience