Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging
Bidur Paudel, Si‐Yeon Jeong, Carolina Peña-Martinez, Alexis D. Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Joy Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, , Marcus E. Peter
The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.
bioRxiv · Sep 8, 2022 · PreprintNeuroscience