Author

Kristina Fredriksen

Northwestern UniversityORCID 0000-0001-6366-8428Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adriana FerreiraiD· 1 shared Alexis D. RickmaniD· 1 shared Allison ChangiD· 1 shared Amira AffanehiD· 1 shared Andrea E. MurmanniD· 1 shared Ashley Haluck-KangasiD· 1 shared Bidur PaudeliD· 1 shared Bradlee L. HeckmanniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Adriana FerreiraORCID

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2 papers

Recent·Most cited

High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoids

Kristina Fredriksen, Siddhi S. Joshi, Allison Chang, Ling Li

This study shows that the HDL-mimetic peptide 4F improves APOE secretion and lipidation in E4 astrocytes and organoids, reducing A{beta}42-induced dysfunction.

bioRxiv · Dec 18, 2025 · PreprintNeuroscience

Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Peña-Martinez, Alexis D. Rickman, Ashley Haluck-Kangas, Elizabeth T. Bartom, Kristina Fredriksen, Amira Affaneh, John A. Kessler, Joseph R. Mazzulli, Andrea E. Murmann, Emily Joy Rogalski, Changiz Geula, Adriana Ferreira, Bradlee L. Heckmann, , Marcus E. Peter

The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.

bioRxiv · Sep 8, 2022 · PreprintNeuroscience