Primary cortical neurons precipitate and extrude large mitochondria-associated calcium-phosphate sheets with a bone-precursor-like ultrastructure
Erik D. Anderson, Christopher A. Cronkite, Philip Rupert Baldwin, Carlota Abella, Joseph G. Duman, Ashleigh N. Simmonds, M. Neal Waxham, Kimberley F. Tolias, Steven J. Ludtke
The paper shows that wild-type cortical neurons form and extrude calcium-phosphate sheets associated with mitochondria, suggesting a role in pathological calcification in neurological disorders.
Molecular Brain · Jan 9, 2026Peer-reviewedNeuroscience