Kimberley F. Tolias

Infant gut microbiomes contribute to metabolic states that impact brain function

The paper shows that infant gut microbiomes influence metabolic states that affect brain function, with interventions restoring normal behavior in mice.

Primary cortical neurons precipitate and extrude large mitochondria-associated calcium-phosphate sheets with a bone-precursor-like ultrastructure

The paper shows that wild-type cortical neurons form and extrude calcium-phosphate sheets associated with mitochondria, suggesting a role in pathological calcification in neurological disorders.

The contribution of de novo coding mutations to meningomyelocele

The paper identifies de novo mutations contributing to meningomyelocele risk by analyzing trios and finding damaging mutations in 22.3% of cases.

Tiam1-mediated synaptic plasticity drives comorbid depressive symptoms in chronic pain

This study identifies Tiam1-mediated synaptic plasticity in the ACC as a driver of depressive symptoms in chronic pain and shows that ketamine's antidepressant effects are mediated by blocking this pathway.

Cell type composition and circuit organization of neocortical radial clones

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.