Steven J. Ludtke

This study identifies lipoprotein-mediated endocytosis as a conserved mechanism for cationic cell-penetrating peptides across animal lineages, showing it modulates their antimicrobial function.

The paper shows that wild-type cortical neurons form and extrude calcium-phosphate sheets associated with mitochondria, suggesting a role in pathological calcification in neurological disorders.

The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.

TomoScore assesses cryo-ET tomogram quality for cellular annotation using a deep learning model, identifying optimal electron dose ranges to improve data processing efficiency.

This study uses cryo-electron tomography to reveal the molecular structures of two tubulin-based cytoskeleton structures in Toxoplasma gondii, showing their architecture and role in invasion.