Adaptive regulation of dNTP homeostasis confers osimertinib resistance in EGFR mutant non-small cell lung carcinoma
Qian Xie, Yingying Wang, Anthony Fernandez, Yi Lei, Yuanhang Gong, Jessica D. Hess, Lin Yang, Di Xin, Terence Marques Williams, Li Zheng, Binghui Shen, Min Li
This study identifies dNTP homeostasis regulation as a mechanism of osimertinib resistance in EGFR-mutant NSCLC, revealing therapeutic targets through two regulatory axes.
Cancer Research · Apr 6, 2026Peer-reviewedCancer Biology