Anthony Fernandez

NEIL2 regulates RNA polymerase II dynamics to suppress transcription replication conflicts in pancreatic cancer

This study identifies NEIL2 as a regulator of RNA polymerase II dynamics that suppresses transcription replication conflicts in pancreatic cancer cells.

The function of human PIF1 in G quadruplex formation and replication stress response at ALT telomeres

This study investigates the role of human PIF1 in ALT telomere maintenance, showing its involvement in DNA damage, G4 formation, and replication stress response, with implications for cancer therapy.

Adaptive regulation of dNTP homeostasis confers osimertinib resistance in EGFR mutant non-small cell lung carcinoma

This study identifies dNTP homeostasis regulation as a mechanism of osimertinib resistance in EGFR-mutant NSCLC, revealing therapeutic targets through two regulatory axes.

JMJD1B-mediated FEN1 demethylation allows timely switching of Okazaki fragment maturation core enzymes to avoid mutagenic flap ligation by PARP1-LIG3

DNA2 and MSH2 activity collectively mediate chemically stabilized G4 for efficient telomere replication

The paper shows DNA2 and MSH2 work together to remove G4 structures at telomeres, preventing replication issues and telomere instability.