Yi Lei

This paper shows that XPF degrades 3' flaps in human cells when FEN1 is deficient, enabling Okazaki fragment maturation and preventing DNA damage.

This study identifies context-dependent roles of PARP1 in regulating Okazaki fragment maturation by controlling 5' flap dynamics and DNA ligation processes.

The paper identifies DNA replication errors as a source of small inverted triplication (SIT) structural variants in yeast, showing their formation mechanism and characteristics.

This study identifies dNTP homeostasis regulation as a mechanism of osimertinib resistance in EGFR-mutant NSCLC, revealing therapeutic targets through two regulatory axes.