Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer
Alan M. Elder, Heather R. Fairchild, Kelsey T. Kines, Lauren M. Cozzens, Alexandria R Becks, Jill E. Slansky, Steven Michael Anderson, Traci Renae Lyons
This study shows that SEMA7A promotes PD-L1 expression in mammary tissue during involution and in tumors, and a SEMA7A-targeting antibody reduces tumor growth and restores T cell function.
Cell Reports · May 1, 2025Peer-reviewedCancer Biology