Traci Renae Lyons

This study identifies SOX9 and SEMA7A as regulators of cell plasticity in postpartum mammary glands and links their dysregulation to breast cancer progression and metastasis.

This study investigates SEMA7A's role in ER+ breast cancer resistance to endocrine therapy and shows that targeting SEMA7A with antibodies or PI3K inhibitors reduces tumor growth in preclinical models.

This study shows that SEMA7A promotes PD-L1 expression in mammary tissue during involution and in tumors, and a SEMA7A-targeting antibody reduces tumor growth and restores T cell function.