Spatially enforced engagement of PD-1⁺ T cells with AXL⁺ cells reprograms the tumor microenvironment and overcomes anti-PD-1 resistance
Ksenia M. Yegodayev, Gregory Perelman, Tamar Shami…·Moshe Elkabets
This study develops a bispecific antibody that enhances T-cell engagement with AXL+ cells, improving anti-PD-1 therapy efficacy in HNSCC by remodeling the tumor microenvironment.