Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs
Xing Zheng, Benjamin M. Sutter, Anna V. Freitas, Ngoc Khoi Dang, Nicholas T. Ingolia, Benjamin P. Tu
The paper shows that under metabolic stress, many mRNAs lack cap methylation, yet they are still functional, suggesting cap methylation is a stress-responsive regulatory layer.
bioRxiv · Oct 29, 2026 · PreprintCell Biology