Benjamin P. Tu

Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs

The paper shows that under metabolic stress, many mRNAs lack cap methylation, yet they are still functional, suggesting cap methylation is a stress-responsive regulatory layer.

Yeast Rpd3L histone deacetylase couples nutrient shifts to genome-wide chromatin reprogramming

This study shows that the yeast Rpd3L complex links nutrient changes to chromatin reprogramming by deacetylating histones at active promoters, ensuring transcriptional control during metabolic shifts.

SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

The paper identifies CFIm25 as a regulator of MAT2A intron detention and intracellular SAM levels through splicing mechanisms.

Human to yeast pathway transplantation: cross-species dissection of the adenine de novo pathway regulatory node

The paper transplants the human adenine de novo pathway into yeast to study regulatory mechanisms, finding that PPAT/ADE4 is a central regulatory node influenced by metabolites and mutations.