Author
Broad InstituteORCID 0000-0002-3332-5747Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Manraj S. Gill, Isabelle Kim, James R. Xue…·Gene‐Wei Li
The paper shows that long-range mRNA folding affects ribosome binding site accessibility, leading to gene expression regulation and sequence evolution constraints.
Matthew J. Christmas, Irene M. Kaplow, Diane P. Genereux…·Michaela K. Halsey
A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.
Patrick F. Sullivan, Jennifer R. S. Meadows, Steven Gazal…·Arcadi Navarro
The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.
Dustin S. Griesemer, James R. Xue, Steven K. Reilly…·Pardis Christine Sabeti
The paper identifies causal 3'UTR variants linked to human disease and evolution using a new high-throughput assay and functional analysis.