Thirty years of fluconazole therapy selects an azole-resistant Candida albicans isolate with a pre-adapted physiological, metabolic and structural state
Claudia Marcela Parra‐Giraldo, Julio Jesús Estrada‐Valbuena, Yerly Vargas‐Casanova, Irene Aldea, Luis Felipe Clemente, Concha Gil, Raquel Martínez‐López, Lucía Monteoliva
This study identifies a fluconazole-resistant C. albicans isolate that exhibits metabolic and mitochondrial adaptations after 30 years of antifungal exposure, suggesting new therapeutic targets.
bioRxiv · Sep 21, 2026 · PreprintMicrobiology