Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Océane Dufies, Marco Di Gioia, Roberto Spreafico, Piao Jian Tan, James R. Springstead, Sean A Prell, Junning Case, Ce Gao, Kevin Wei, Hao Wu, Ivan Zanoni
The paper shows that chronic exposure to oxidized phospholipids primes and activates NLRP3 via NRF2, independent of microbial cues, contributing to atherogenesis.
bioRxiv · Oct 29, 2025 · PreprintImmunology