Mauricio Sáez

Exploring Single-Cell Gene Regulatory Dynamics in Rett Syndrome

This study uses single-cell transcriptomic data from human patients to analyze gene regulatory dynamics in Rett syndrome, identifying master regulators and potential therapeutic targets.

Random Forest approach for the identification of relationships between epigenetic marks and its application to robust assignment of chromatin states

This paper introduces a random forest-based method to infer epigenetic marks and assign chromatin states with fewer experimental data.

Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort

This study characterizes the mutational landscape of high-grade gliomas in a Chilean cohort, identifying novel mutations and highlighting genetic differences compared to non-Latin American populations.

Transcriptional and Histone acetylation changes associated with CRE elements expose key factors governing the regulatory circuit in early stage of Huntington's disease models.