Sarah L. Rouse

An octadecameric O-glucosyltransferase generates diversity in antibody epitopes on variant surface antigens in African trypanosomes

This study identifies ESAG3 as an O-glucosyltransferase that modifies VSG3 to alter antibody epitopes and influence infection outcomes in African trypanosomes.

Bacteroidales Secreted Antimicrobial Protein-1 receptor recognition is coupled to protease-activation to form bactericidal pores.

This study defines the mechanism of BSAP-1 toxin action, showing receptor recognition and protease-activation lead to pore formation in target cells.

Design principles of a membrane-spanning ubiquitin ligase

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.

Human class B1 GPCR modulation by plasma membrane lipids

The paper uses molecular dynamics simulations and FRET assays to study lipid interactions with class B1 GPCRs, revealing state-dependent and conserved lipid binding patterns.

An integrative modelling approach to the mitochondrial cristae

The paper presents a workflow to create a comprehensive model of a mitochondrial crista junction using a coarse-grained representation and molecular modelling.

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

This study identifies and validates cholesterol binding sites on GLP-1R in pancreatic beta cells, showing their role in receptor function and potential for drug design.

Characterization of the mutational landscape of high-grade gliomas in a Latin American cohort

This study characterizes the mutational landscape of high-grade gliomas in a Chilean cohort, identifying novel mutations and highlighting genetic differences compared to non-Latin American populations.