Barry S. Taylor

The paper shows that mtDNA mutations in tumors are shaped by OXPHOS complexes, with specific mutational patterns in Complex I and V, and links these to improved survival in colorectal cancer.

The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.

This paper presents a pipeline to unify RNA-seq data from different studies by removing batch effects, enabling cross-study analysis.