Minsoo Kim

The paper introduces mtDIVE, a random mtDNA mutagenesis platform, to study genotype-phenotype associations in metabolic contexts and lineages, revealing lineage-specific effects and mutation-specific impacts.

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

The paper shows that mtDNA mutations in tumors are shaped by OXPHOS complexes, with specific mutational patterns in Complex I and V, and links these to improved survival in colorectal cancer.