NeuroscienceeLifePeer-reviewed
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS
Janani Parameswaran, Nancy Zhang, Elke Braems…·Jie Jiang
This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.
25 citations