Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent integrated stress response in C9orf72 FTD/ALS
Janani Parameswaran, Nancy Zhang, Elke Braems, Kedamawit Tilahun, Devesh C. Pant, Keena Yin, Seneshaw Asress, Kara Heeren, Anwesha Banerjee, Emma Davis, Samantha L. Schwartz, Graeme L. Conn, Gary Jonathan Bassell, Ludo Van Den Bosch, Jie Jiang
This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.
eLife · Apr 19, 2023Peer-reviewedNeuroscience