Devesh C. Pant

This study creates a mouse model with a heterozygous deletion of Sptlc1 exon 2 and finds no motor defects or ALS-like neuropathology, but homozygous mutants die prematurely.

This study identifies novel plasma proteins associated with KIF5A-linked SPG10 and ALS using targeted proteomics, revealing distinct proteomic signatures and potential biomarkers.

The paper investigates how both loss and gain of kinesin functions lead to axonal degeneration through microtubule curling in Drosophila neurons.

This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.

This study shows that KIF5A ΔExon27 mutant causes neuronal toxicity through gain of function by forming aggregates and increasing motor activity.