Graeme L. Conn

This study determines the structural basis of Trm10's specific tRNA methylation by capturing its post-catalytic states using cryo-EM and MD simulations.

This study compares sfRNA secondary structure dynamics in vitro and in infected cells across multiple flaviviruses, identifying conserved and variable structural features.

This study identifies that RsmF activity in E. coli depends on prior modification of 16S rRNA helix 44 by RsmE and RsmH, revealing an order of operations for ribosome biogenesis modifications.

KNexPHENIX improves structural models from cryo-EM and crystallography by refining them with better stereochemistry while maintaining model-to-map correlation and reducing overfitting.

This study identifies a conserved SARS-CoV-2 5-UTR stem-loop region that activates OAS1, a key antiviral protein, through structural and functional analyses.

This study determines the cryo-EM structure of the RsmI-30S complex and reveals how RsmI recognizes and modifies the 16S rRNA C1402 nucleotide.

The paper identifies three substrate classes for the MexXY-OprM efflux system in Pseudomonas aeruginosa and classifies trimethoprim as a new substrate.

This study identifies distinct roles of arginine fingers in Rvb1 and Rvb2 ATPases, showing how changes in their active sites affect catalytic activity, protein interactions, and cellular functions.

This study identifies that antisense C4G2 repeat expanded RNAs, but not sense G4C2, activate the PKR/eIF2-dependent integrated stress response in C9orf72 FTD/ALS, leading to neuronal toxicity.