Achim Klug

This paper introduces a photogrammetry-based platform for automated small animal stereotaxic surgery, improving targeting accuracy and surgical speed through high-resolution 3D skull reconstructions.

The paper develops a computational model to synthesize auditory brainstem responses (ABRs) and links ABR morphology changes to neuronal alterations in aging and autism animal models.

This study uses prepulse inhibition of acoustic startle to assess spatial hearing and temporal processing in Mongolian gerbils, finding thresholds match those from operant conditioning.

This study develops an in-vivo optogenetic method to control MNTB activity in gerbils with fast and precise temporal control, enabling research on sound localization.

This paper introduces a sapphire-based optrode that combines high-intensity LED optogenetic stimulation with low-noise neural recording, demonstrating its effectiveness in vivo.

This study identifies age-related myelin deficits in the auditory brainstem pathway as a cause of spatial hearing deficits in aging Mongolian gerbils.

This study examines age-related declines in spatial hearing and auditory temporal processing abilities, finding that performance deficits are not solely due to hearing thresholds but also to central auditory processing changes.

The paper introduces GEMsort, a multichannel neural spike sorting algorithm that reduces data volume and improves sorting speed using signal processing modifications.

This study uses a spiking neural network model to show that axon myelination thickness affects ITD detection in the auditory brainstem, with optimal sensitivity achieved through contralateral inhibition via thicker myelinated axons.

This study investigates myelination deficits in the auditory brainstem of FXS mice, finding reduced myelin thickness and increased g-ratio, with increased oligodendrocytes and precursors.

This study investigates spatial hearing impairments in Fmr1 knockout mice, finding decreased prepulse inhibition and increased response latency during sound localization tasks.

This paper presents a de novo genome assembly of the Mongolian gerbil using Illumina sequencing and supports it with transcriptome data from 27 tissues, identifying 36,019 protein-coding genes.