Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors
Xudong Wang, Liwei Xiong, Ying Zhu, Sixiu Liu, Wenfeng Zhao, Xinyuan Wu, Mengnisa Seydimemet, Linjie Li, Peiqi Ding, Xian Lin, Jiaxiang Liu, Xuan Wang, Zhiqiang Duan, Weiwei Lu, Yanrui Suo, , Xiaojie Lu
This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.
Journal of the American Chemical Society · Nov 22, 2024Peer-reviewedBiochemistry