Author

Hangchen Hu

Chinese Academy of SciencesORCID 0000-0002-1063-9292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

Wenfeng ZhaoiD· 2 shared Guofeng CheniD· 1 shared Haixia SuiD· 1 shared Jiaxiang Liu· 1 shared Jinfeng Yue· 1 shared Lianghe MeiiD· 1 shared Linjie LiiD· 1 shared Liwei Xiong· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Wenfeng ZhaoORCID

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2 papers

Recent·Most cited

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

Xudong Wang, Liwei Xiong, Ying Zhu, Sixiu Liu, Wenfeng Zhao, Xinyuan Wu, Mengnisa Seydimemet, Linjie Li, Peiqi Ding, Xian Lin, Jiaxiang Liu, Xuan Wang, Zhiqiang Duan, Weiwei Lu, Yanrui Suo, , Xiaojie Lu

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

Journal of the American Chemical Society · Nov 22, 2024Peer-reviewedBiochemistry

Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease

Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Guofeng Chen, Minjun Li, Yechun Xu

The paper identifies C270 as a novel allosteric site for modulators of SARS-CoV-2 PLpro, revealing a mechanism for covalent activation and inhibition.

bioRxiv · Mar 30, 2022 · PreprintMolecular Biology