Author

Wenfeng Zhao

Chinese Academy of SciencesORCID 0000-0003-2517-4747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:virus· 3 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Assay:protein structure· 1 Assay:structural biology· 1

Frequent Co-Authors

Haixia SuiD· 3 shared Hangchen HuiD· 2 shared Hualiang JiangiD· 2 shared Jingshan SheniD· 2 shared Minjun LiiD· 2 shared Yechun XuiD· 2 shared Chang‐Qiang Ke· 1 shared Chunyou MaoiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

Haixia SuORCID

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4 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedNov 22, 2024

Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Non-structural Proteins Inhibitors

Xudong Wang, Liwei Xiong, Ying Zhu…·Xiaojie Lu

This study uses covalent DNA-encoded libraries to discover inhibitors targeting SARS-CoV-2 proteases 3CLpro and PLpro, identifying novel compounds with potent activity and unique binding modes.

34 citationstop 1%

virusstructural biology

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Molecular BiologybioRxivPreprintMar 30, 2022

Identification of C270 as a novel site for allosteric modulators of SARS-CoV-2 papain-like protease

Hangchen Hu, Qian Wang, Haixia Su…·Yechun Xu

The paper identifies C270 as a novel allosteric site for modulators of SARS-CoV-2 PLpro, revealing a mechanism for covalent activation and inhibition.

1 citation

experimental assay

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Molecular BiologySciencePeer-reviewedMay 1, 2020

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Wanchao Yin, Chunyou Mao, Xiaodong Luan…·H. Eric Xu

This study reports the structure of SARS-CoV-2 RdRp with and without Remdesivir, showing how the drug inhibits viral RNA replication by terminating chain elongation.

1,219 citationstop 1%

virusexperimental assay

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Molecular BiologybioRxivPreprintApr 13, 2020

✦ In-depth digest

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Haixia Su, Sheng Yao, Wenfeng Zhao…·Yechun Xu

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

143 citations

virusprotein structure

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