Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation
Rijan Gurung, Chang Jie Mick Lee, Elisa Anamaria Liehn, Siti Bunga Nurjanah, Ren Minqin, Jeroen Anton van Kan, Erielle Villanueva, Junedh Amrute, Shaun Seh Ern Loong, Matthew Andrew Ackers-Johnson, Francesco Paolo Ruberto, Shi Ling Ng, Yi Xuan Loo, Jiapeng Chu, Xiao Yun Lin, , Roger Foo
The paper identifies macrophage-like vascular smooth muscle cells as dominant in early atherosclerosis and shows that targeting iron regulation inhibits their transition.
bioRxiv · May 22, 2025 · PreprintGenomics