Thiruma Valavan Arumugam

This study shows that parental intermittent fasting induces intergenerational molecular changes in the brain, affecting sensory pathways and sex-dependent gene expression in offspring.

This study identifies tissue-specific and shared molecular adaptations to intermittent fasting in liver, brain, and muscle using proteomics and transcriptomics.

This study shows that S100A8/A9 inhibition reduces splenic myelopoiesis and improves stroke outcomes by decreasing neutrophilia and infarct size.

This study shows HDAC inhibition changes microglial activity and spatial distribution in stroke brains, promoting neuroprotection and recovery in mice.

This study shows intermittent fasting changes chromatin accessibility and gene expression in brain and muscle tissues of mice, affecting metabolic and functional pathways.

This study shows that parental time-restricted feeding affects offspring metabolic traits differently in males and females, offering protection against diet-induced metabolic issues.

This study shows that intermittent fasting reduces neurovascular damage and oxidative stress in a mouse model of vascular dementia.

This paper reports a preclinical randomized trial showing that anti-IL-17A treatment reduces infarct volume in a mouse stroke model.

This study compares hippocampal gene expression in young and old mice under chronic hypoperfusion and aging, identifying shared molecular pathways linked to vascular dementia.

This study uses multi-omics analyses to investigate how different intermittent fasting regimens affect heart function and molecular pathways in mice.

This study shows that AIM2 inflammasome activation contributes to brain injury and cognitive impairment in a mouse model of vascular dementia.

This study shows intermittent fasting modulates H3K9me3 epigenetic marks and transcriptomic changes in mouse cerebellum, with lasting effects after refeeding.