Matthew Andrew Ackers-Johnson

High throughput single-cell RNA sequencing of intact adult cardiomyocytes and non-myocytes using a split-pool approach

This paper develops a high-quality, scalable workflow for whole-cell single-cell RNA sequencing of adult cardiomyocytes and non-myocytes using in-cell ligation and split-pool barcoding, improving data quality and throughput.

Chromatin landscape and enhancer-gene interactiondifferences between three cardiac cell types

The paper identifies cell-type-specific enhancer-gene interactions in cardiac cells and maps disease-associated SNPs to enhancers in endothelial cells.

Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation

The paper identifies macrophage-like vascular smooth muscle cells as dominant in early atherosclerosis and shows that targeting iron regulation inhibits their transition.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

This study presents whole-genome sequencing data from 4,810 Singaporeans across three ethnic groups, revealing genetic structure, admixture, and improved imputation for Asian and Oceanian populations.