Enhancing the outcome of crystallographic screening for efficient drug discovery by choosing the right crystal form
Tatjana Barthel, J. Wollenhaupt, Laila S. Benz, Patrick Y. A. Reinke, Linlin Zhang, Melanie Oelker, F. Lennartz, Helena Taberman, U. Müeller, Alke Meents, Rolf Hilgenfeld, Manfred S. Weiss
This study shows that selecting the correct crystal form significantly improves hit rates in crystallographic fragment screening for drug discovery.
bioRxiv · Aug 20, 2025 · PreprintBiochemistry