Alke Meents

FoXSight identifies weak binding events in crystallographic fragment screening by detecting target-specific density features in noisy electron density maps.

The paper uses statistical crystallography to model correlated motions in SARS-CoV-2 Mpro and shows how dimerization affects catalytic activity through structural links.

This study shows that selecting the correct crystal form significantly improves hit rates in crystallographic fragment screening for drug discovery.