Author

Francis Isidore G. Totañes

University of CambridgeORCID 0000-0002-3419-5243Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:plant (other)· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Catherine J. MerrickiD· 1 shared Clara Herrera-Arozamena· 1 shared David R. WestheadiD· 1 shared Glenn A. McConkeyiD· 1 shared Mathew V. JonesiD· 1 shared Michael A. BoemoiD· 1 shared Richard FosteriD· 1 shared Sarah E Chapman· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

Catherine J. MerrickORCID

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2 papers

Recent·Most cited

Validated Antimalarial Drug Target Discovery using Genome-Scale Metabolic Modelling

Supannee Taweechai, Francis Isidore G. Totañes, David R. Westhead, Clara Herrera-Arozamena, Richard Foster, Glenn A. McConkey

This study validates a new antimalarial drug target using genome-scale metabolic modeling and experimental testing of inhibitors against Plasmodium falciparum UCK.

bioRxiv · Mar 26, 2025 · PreprintMicrobiology

DNA replication dynamics are associated with genome composition in Plasmodium species

Francis Isidore G. Totañes, Sarah E Chapman, Subash Kumar Rai, Mathew V. Jones, Michael A. Boemo, Catherine J. Merrick

This study compares DNA replication dynamics in two Plasmodium species with different A/T-content genomes, finding that P. falciparum has slower and more consistent replication fork speeds despite high A/T bias.

Nucleic Acids Research · Feb 5, 2025Peer-reviewedMicrobiology