David R. Westhead

Conventional dendritic cells type I with an enhanced type-I-IFN signaling underpin anti-tumor immune responses in brain metastases

This study identifies conventional dendritic cells type 1 (cDC1s) as critical for anti-tumor immunity in brain metastases, showing their unique role in promoting CD8+ T cell responses and enhancing immunotherapy efficacy.

Validated Antimalarial Drug Target Discovery using Genome-Scale Metabolic Modelling

This study validates a new antimalarial drug target using genome-scale metabolic modeling and experimental testing of inhibitors against Plasmodium falciparum UCK.

Integration of chromatin accessibility and gene expression data with cisREAD reveals a switch from PU.1/SPIB-driven to AP-1-driven gene regulation during B cell activation

The paper uses cisREAD to integrate chromatin accessibility and gene expression data from B cell differentiation, showing a shift from PU.1/SPIB to AP-1 driven gene regulation during activation.

Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1 mediated HSR

The paper identifies transcellular chaperone signaling (TCS) as a gut-to-muscle stress response in C. elegans that bypasses HSF-1-mediated heat stress resistance.

Defining common principles of gene co-expression refines molecular stratification in cancer

The paper defines common gene co-expression principles across cancers to improve molecular stratification by identifying consistent expression modules and their associations with mutation states.