Author

Gayathri Bommakanti

AstraZeneca (United States)ORCID 0000-0002-3420-2802Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Aatman S. DoshiiD· 1 shared Aparna GorthiiD· 1 shared Deanna A. MeleiD· 1 shared Elizabeth S. JaenschiD· 1 shared Iswarya Karapa Reddy· 1 shared James H. KurasawaiD· 1 shared Jason Daniel BuenrostroiD· 1 shared Laura B. PrickettiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

Aatman S. DoshiORCID

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1 paper

Recent·Most cited

Degradation of IKAROS prevents epigenetic progression of T cell exhaustion in a novel antigen-specific assay

Tristan Tay, Gayathri Bommakanti, Elizabeth S. Jaensch, Aparna Gorthi, Iswarya Karapa Reddy, Yan Hu, Ruochi Zhang, Aatman S. Doshi, Sin Lih Tan, Verena Brucklacher-Waldert, Laura B. Prickett, James H. Kurasawa, Michael Glen Overstreet, Steven W. Criscione, Jason Daniel Buenrostro, Deanna A. Mele

The paper develops an antigen-specific assay for T cell exhaustion and identifies IKAROS as a driver of exhaustion, showing that iberdomide prevents exhaustion by blocking chromatin remodeling.

bioRxiv · Feb 22, 2024 · PreprintGenomics