Tristan Tay

The paper develops an antigen-specific assay for T cell exhaustion and identifies IKAROS as a driver of exhaustion, showing that iberdomide prevents exhaustion by blocking chromatin remodeling.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.