Single-nucleus RNA-seq of normal-appearing brain regions in relapsing-remitting vs. secondary progressive multiple sclerosis
Yasuyuki Kihara, Yunjiao Zhu, Deepa Jonnalagadda, William J. Romanow, Carter R. Palmer, Benjamin A. Siddoway, Richard R. Rivera, Ranjan Dutta, Bruce D. Trapp, Jerold J. M. Chun
The paper uses snRNA-seq to compare cell type-specific transcriptomic changes between RRMS and SPMS in non-lesioned brain regions, identifying downregulation of astrocytic sphingosine kinases in SPMS.
Frontiers in Cellular Neuroscience · Jun 17, 2022Peer-reviewedNeuroscience