Structural Mechanism of Filamentation Induced Dampening of GTP Inhibition of Glutamate Dehydrogenase
Zelin Shan, Noura I. Darwish, Andres Rivero-Gamez, Timothy S. Strutzenberg, Dmitry Lyumkis, Nancy C. Horton
This study uses cryo-EM to show how filamentation in bovine GDH alters its allosteric response to GTP inhibition, revealing structural mechanisms with implications for disease treatment.
bioRxiv · Sep 25, 2026 · PreprintBiochemistry