Author

Nancy C. Horton

University of ArizonaORCID 0000-0003-2710-8284Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Andres Rivero-GameziD· 2 shared Dmitry LyumkisiD· 2 shared Zelin ShaniD· 2 shared Noura I. Darwish· 1 shared Timothy S. StrutzenbergiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

Andres Rivero-GamezORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 25, 2026

Structural Mechanism of Filamentation Induced Dampening of GTP Inhibition of Glutamate Dehydrogenase

Zelin Shan, Noura I. Darwish, Andres Rivero-Gamez…·Nancy C. Horton

This study uses cryo-EM to show how filamentation in bovine GDH alters its allosteric response to GTP inhibition, revealing structural mechanisms with implications for disease treatment.

1 citation

protein structureexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedJul 14, 2024

Two-Metal Ion Mechanism of DNA Cleavage by Activated, Filamentous SgrAI

Zelin Shan, Andres Rivero-Gamez, Dmitry Lyumkis, Nancy C. Horton

The paper presents two cryo-EM structures of filamentous SgrAI to elucidate the two-metal ion mechanism of DNA cleavage during enzymatic activity.

3 citations

cryo-EMexperimental assay

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