Author

Guanwen Chen

National Cheng Kung UniversityORCID 0000-0002-3435-0725Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Day‐Yu ChaoiD· 2 shared Jan K. MarzinekiD· 2 shared Palur Venkata RaghuvamsiiD· 2 shared Peter John BondiD· 2 shared Shang‐Rung WuiD· 2 shared Chun-Hsiung WangiD· 1 shared Fan-Chi Chen· 1 shared Jedhan Ucat Galula· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Day‐Yu ChaoORCID

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2 papers

Recent·Most cited

An Integrative Approach to Rational Engineering of Dengue Virus-Like Particles

Palur Venkata Raghuvamsi, Fan-Chi Chen, Shang‐Rung Wu, Guanwen Chen, Peter John Bond, Day‐Yu Chao, Jan K. Marzinek

This study uses multiscale modeling, lipidomics, and experiments to engineer stable and immunogenic dengue virus-like particles by modifying protein-lipid interactions.

Cell Reports Physical Science · Sep 1, 2025Peer-reviewedBiophysics

Structural Insights into Immature Dengue Virus-Like Particles Revealed by Cryo-EM and Molecular Dynamics Simulations

Palur Venkata Raghuvamsi, Guanwen Chen, Day‐Yu Chao, Ya‐Na Wu, Jedhan Ucat Galula, Chun-Hsiung Wang, Peter John Bond, Jan K. Marzinek, Shang‐Rung Wu

This study presents the cryo-EM structure of immature dengue serotype 2 VLPs and uses MD simulations to reveal their maturation mechanism and lipid dependency.

bioRxiv · Jan 21, 2025 · PreprintBioinformatics